Talkeetna is located at 62°18′41″N150°5′13″W (62.311397, -150.087053) at the confluence of three rivers, the Susitna, Chulitna and Talkeetna. The Talkeetna townsite was established in 1919 when the railroad surveyed and auctioned 80 lots. The average price at the sale was $14.25. Flightseeing, rafting, mountain biking, hiking, camping, fishing and hunting make up a large portion of the local economy. Talkeetna is a 2.5 hour drive from Anchorage, the largest city in Alaska. The core downtown area is classified as a National Historic Site, with buildings dating from the early 1900s including Nagley's General Store, Fairview Inn and the Talkeetna Roadhouse.
According to the United States Census Bureau, the CDP has a total area of 42.9 square miles (111 km2), of which, 41.6 square miles (108 km2) of it is land and 1.4 square miles (3.6 km2) of it (3.19%) is water.